A meta-analysis by Nikolopoulos et al., which based on 17 studies showed that there was no association of the TNF-α promoter −308G/A polymorphism with periodontitis while another meta-analysis by Song et al. A variety of single nucleotide polymorphisms of various signaling factors, receptors, connective tissue components, enzymes involved in the host defense against the invading microbes have been reported by several researchers. Epub 2019 Jun 13. Different variations in frequency of some alleles in different populations have been observed. It is encoded on gene at 1q31-q32. The reason for the large increase in publicati… found significant association between IL-6 −1363 G/T and IL-6R +48,892 A/C polymorphisms with periodontitis in Chinese population [12]. Our team is growing all the time, so we’re always on the lookout for smart people who want to help us reshape the world of scientific publishing. found positive associations between IL-10 SNP and periodontitis in Swedish and Brazilian population [14]. The major regions of interleukin-10 single nucleotide polymorphisms studied were −1082, −819, and −592. Gene localized at 6p21.3. Gurumoorthy Kaarthikeyan and Swarna Meenakshi (November 11th 2019).  |  2020 Feb;24(2):833-840. doi: 10.1007/s00784-019-02973-2. Licensee IntechOpen. Periodontal disease and bacterial vaginosis as genetic and environmental markers for the risk of spontaneous preterm labor and preterm birth. Periodontal disease (PD) and coronary artery disease (CAD) are common diseases characterized by an overaggressive inflammatory response to diverse stimuli. Genetic research has focused on understanding how these responses work and also how these responses differ between different individuals. Not all the individuals having the similar amount of plaque and calculus develop the periodontitis. Therefore, any alteration in FcyR expression and function would alter host immune responses against periodontal pathogens and hence susceptibility to periodontal diseases . 2012 Nov;225(1):1-10. doi: 10.1016/j.atherosclerosis.2012.05.015. However, conflicting results have been reported because of the heterogeneticity of the studies. Up to 30% of the population may have some genetic susceptibility to periodontal disease. Biofilm and periodontal microbiology 9. Periodontitis is a chronic inflammatory disease with multifactorial etiology. There has been a rapid increase in interest in understanding the relationship between periodontal disease and cancer risk; twice as many original observational studies were published with measures of periodontal disease (i.e., not including studies using tooth number as surrogate of periodontal disease) in the past few years (n = 12; 2011–2016) as were published during the 20 years prior to 2011 (n = 6) (Web Tables 1 and 2, available at http://aje.oxfordjournals.org/). These genes encode immune receptors and various molecules involved in the signal transduction pathways that play an essential role in up regulation or down regulation of the immune response essentially the inflammatory reaction in response to a stimuli.  |  Login to your personal dashboard for more detailed statistics on your publications. The anaerobic bacteria have been implicated as the main etiological factor for periodontal destruction. Whereas PD leads to destruction of the tooth-supporting structures, CAD is a chronic inflammatory condition ultimately causing myocardial infarction via narrowing and occluding of blood vessels. For example, some people with severe periodontal disease have genetic factors that affect the immune factor interleukin-1 (IL-1), a cytokine involved in the inflammatory response. It highlights suggestive loci that could play an important role in periodontitis. A biomarker is a substance that could indicate a biologic state and is an objective measure to evaluate the current and future disease activity. Clipboard, Search History, and several other advanced features are temporarily unavailable. Epub 2012 May 23. The role of dental calculus and other local predisposing factors 8. Amelogenesis imperfecta either causes problems in enamel hardening (mineralization) of normal amounts of enamel, or causes less than normal enamel production. Thus, the genetic changes of the MMPs and TIMPs might play a role in the etiopathogenesis of periodontitis. that showed evidence of association with severity of periodontitis and colonization of microorganisms [22]. Epub 2014 Dec 2. We share our knowledge and peer-reveiwed research papers with libraries, scientific and engineering societies, and also work with corporate R&D departments and government entities. in their systematic review and meta-analysis studied 13 studies and found that IL-1α and IL-1β (IL-1α (−889) C > T, IL-1α (+4845) G > T, IL-1β (+3954) C > T, could be a significant contribution to the risk of developing periodontitis [10]. demonstrated that Asians had a low carriage rate of IL-1α −889 R-allele compared to the other populations [5]. Epub 2013 Jun 27. 2013 Nov 15;22(22):4516-27. doi: 10.1093/hmg/ddt299. Available from: Diagnostic and Adjunctive Non-surgical Considerations, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India. did not find any significant association between interleukin-1β (+3954) polymorphism with chronic periodontitis in Indian population [9]. [2]. IL-1 β is produced by a wide range of periodontal tissues and immune cells and, as such, is considered to have multiple roles in innate and adaptive immune responses to plaque bacteria which feature in the pathogenesis of periodontitis [ 49. In periodontitis, this tissue homeostasis is altered with more destruction of connective tissue components and less inhibition by the TIMPs. Scarel-Caminaga et al. Periodontol 2000. Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. Book on this subject and reach those readers their study found that polymorphism! 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