VERY HIGH means that most of the scientific research agrees. No significant alterations have been noted in follicle-stimulating hormone concentrations following pueraria lobata ingestion. Management of Diabetes Mellitus with Puerarin, a Natural Isoflavone From Pueraria lobata. That's why we don’t sell any advertising or supplements. If taken orally, the generally recommended dosage is a total of 500 mg/day. Slows the Aging Process. It is classified as a noxious weed in many areas, earning the monikers ‘the plant that ate the South’ and ‘foot-a … Ohwi, has been widely used in China and, to a lesser extent, in Japan, Korea, and the U … Many studies cited that the normal Pueraria Mirifica dosage intake is 500mg. The maximal dose of puerarin (172.2 mg/kg) to rat via intraperitoneal injection, and the maximal dose of puerarin (91.3mg/kg) to rabbit via intravenous injection, for 14 consecutive days, nothing abnormal was found in the behavior, blood pictures, biology and organ structures. Information tailored to you, updated every month. Examine.com is intended to be used for educational and information purposes only. Our independent, unbiased approach reveals what works (and what's a waste of time and money). Kudzu: Top 10 powerful benefits, effects, properties! Nevertheless, toxicological data on these herbs and their combination are limited. Thin-layer chromatography analysis has documented varying amounts of phytoestrogens collected from P. mirifica in different locations in Thailand.Malaivijitnond 2006, Cherdshewasart 2007 One of the challenges of large-scale manufacturing of P. mirifica for drugs and cosmetics is resolving these variations in lots. followed by specifically-applicable references. This information relates to an herbal, vitamin, mineral or other dietary supplement. Pueraria Mirifica is also called Kwao Krua or more specifically White Kwao Krua. Radix Puerariae has been traditionally used for the treatment of diarrhea, acute dysentery, deafness and cardiovascular diseases. No significant influence on circulating LDL-C has been noted with supplementation. Using the appropriate dosage of the crude herb, as indicated in traditional texts, can be elaborated from work done with isolated active components in a standard dosage form. Puerariae Lobatae Radix (PLR) is the dried root of the leguminous plant Pueraria lobata and is a common component of health products and medicines. So far, scientific support for the benefits of kudzu is limited. The team includes nutrition researchers, registered Become an Examine.com member to get access to the latest research. We have a strict editorial process. View abstract. Bonus: unlock the supplement Human Effect Matrix and all health topics on Examine.com. All factual claims are followed by specifically-applicable references. The Human Effect Matrix summarizes human studies to tell you what effects She is known worldwide as The Cosmetics Cop and creator of Paula’s Choice Skincare. The plant species P. mirifica (pueraria) belongs to the Fabaceae, or bean, subfamily, and its tuberous roots contain several phytoestrogens.Manonai 2007 P. mirifica is a woody vine commonly found in forests throughout ThailandMalaivijitnond 2006 with 28 cultivars presently documented. Another possible health benefit of Pueraria mirifica is its potential to … Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Avoid use during pregnancy and lactation because of the lack of clinical data and the plant's phytoestrogen activity. herbal extract of P. lobata and S. baicalensis as a therapeutic agent for stroke and further confirm the safety of the combined use of P. lobata and S. baicalensis in clinical practice. Pueraria mirifica has been lauded as a natural supplement for various conditions. Another component, known as PE-D, affected the growth in a dose-dependent and time-dependent manner on some breast cancer cell lines (MCF-7, MDAMB-231), and on the growth of ovarian (2774) and cervical cancer cells (HeLa).Baek 2003, Jeon 2005 The estrogenic effect of some components in P. mirifica has been compared with estradiol, a major estrogen in humans.Jeon 2005, Cherdshewasart 2008 The rank order of phytoestrogen potency is: deoxymiroestrol; miroestrol; 8-prenylnaringenin; coumestrol; genistein/equol; daidzein; resveratrol.Matsumura 2005P. Scientific research does not always agree. Avoid use if hypersensitive to any of the components of product. Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata. 14 June 2018, Our evidence-based analysis on pueraria lobata features It is perhaps better known by its Japanese name: kudzu . It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. In sex-hormone–deficient male rats, treatment with P. mirifica root powder completely inhibited bone loss in long bones and axial bones. Each member of our research team is required to have no conflicts of interest, including with supplement Click here to see the full set of references The name "Mirifica" comes from the Latin word "miracle" and means "miracle, wonder." However, there is no literature to support these uses. turmeric, echinacea, saw palmetto, milk thistle, Ginkgo Biloba. Because of its phytoestrogen-like effects, use pueraria with caution if diagnosed with an estrogen-dependent neoplasia, pulmonary embolism, liver dysfunction or disease, or anemia. However, there is no literature to support these uses. No alterations in Apolipoprotein B have been noted, No significant influence of Pueraria lobata on circulating estrogen levels (although it itself may be a phytoestrogen; weak). Kidney damage in people with diabetes (diabetic nephropathy). 2011;31(1):56–59. manufacturers, food companies, and industry funders. It is a fast growing vine that can extend a foot in length each day during the warm season. For topical products, manufacturers suggest a twice-daily topical application to the breast area for 3 to 5 minutes until fully absorbed. Kudzu flowers can be used in the form of tea. A small (n= 52) clinical study evaluated oral P. mirifica at 25 and 50 mg over 6 months in relieving menopausal symptoms, and reported efficacy for both doses. for this page. Last updated on Jul 27, 2020. The length of the menstrual cycle increased in monkeys treated with P. mirifica 10 and 100 mg/day of root extract and disappeared completely in monkeys treated with root extract 1,000 mg/day. However, its health claims aren't proven and using it may pose health risks. The plant's palmate-type leaves are simple or ovate and contain 3 leaflets in 1 petiole. The blue-to-purple flowers are composed of 5 petals and bloom from February to March. Use with caution in patients with abnormal triglycerides or hypercalcemia. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. 10. Please consult a health practitioner before taking kudzu supplements. The medical literature documents the plant's use primarily for menopause, but also for cancer and osteoporosis. Pueraria lobata (Kudzu) is a leguminous perennial vine, native to East & South East Asia, but now widely distributed in sub-tropical regions of the world (EPPO, 2007). Two 250 mg/day capsule or tablet must be taken separately in the morning and in the evening. The researchers suggest 1 mg of P. mirifica is equivalent to 0.52 to 0.75 mcg of ethinyl estradiol.Virojchaiwong 2011. Becoming a member also unlocks our study database of 400+ supplements and their effects on 600+ health outcomes. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. There was no change in blood cells or liver and renal function.Hosoyama 2007, Muangman 2001. mirifica also had an estrogenic effect on a human HepG2 hepatoma cell line that contained an estrogen receptor and a luciferase reporter gene; this evidence indicates that metabolic activation of P. mirifica promotes estrogenic activity.Lee 2002 Another study also documents that estrogenic activity may result from metabolic activation of liver enzymes.Cherdshewasart 2008, The proposed mechanism of action involves strong competitive binding of the plant's phytoestrogens to ER-alpha and/or synthesis suppressor of ER-alpha.Cherdshewasart 2007, Pretreatment of rats with P. mirifica (1,000 mg/kg body weight per day tuberous root powder) resulted in decreased virulence of rat mammary tumor development from 7,12-dimethylbenz(a)anthracene (7,12-DMBA). In alternative medicine, kudzu is typically used for the following conditions: 1. alcoholism 2. menopausal symptoms 3. diabetes 4. common cold 5. fever Not all of these uses are supported by clinical evidence. Overall activity was more potent in female rats than in male rats. Increased triglyceride levels may occur.Manonai 2008, Because of the estrogen-like effect of P. mirifica, use with caution in patients with asthma, diabetes mellitus, epilepsy, migraine, or systemic lupus erythematosus. Clinical observations on the dose-effect relationship of Gegen Qin Lian Decoction on 54 out-patients with type 2 diabetes. The results indicate that kudzu root has minimal toxicity. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. 150+ studies summarized across 25 different categories every month. https://examine.com/supplements/pueraria-lobata/, © 2011-2020 Examine.com Inc | Privacy | Terms of Service | Disclaimer | About Us | Contact Examine.com, Small boost in attention in menopausal women (independent of reductions in symptoms of menopause); needs to be reinvestigated. Based on these studies, the effective dose of kudzu isoflavones is 750 mg per day which amounts to 2.5-3g of standardised kudzu extract. May affect concentration of these medications. 2018;46(8):1771-1789. Gegen (Radix Puerariae Lobatae), the root of Pueraria lobata, is an edible and medicinal herb which has been used in treating diabetic symptoms in the orient for thousands of years.We present an evidence map of the efficacy and safety of Gegen and Gegen formulas (GGFs) that use Gegen as an essential herb for diabetes, and also its mechanism of actions. All factual claims are Although it is consid - ered safe, some studies have reported that PLR has hepatotoxicity and estrogen-like effects. The direction and size of the supplement's impact on The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Here's what the research says so far about kudzu health … Get our free 5-day course on the essentials of supplementation. This is only a brief summary of general information about this product. Select one or more newsletters to continue. If you are to take Pueraria Mirifica for relieving menopausal symptoms, 25mg tablet up to 50mg tablet shall be effective. The ethanol extract had antiproliferative effects on breast cancer cell lines MCF-7, ZR-75-1, MDA-MB-231, SK-BR-3, and Hs578T. 32 unique references to scientific papers. there is, and how strong these effects are. About the Experts. Arm yourself with the knowledge you need to make the right decisions about your health. This page features 32 references. Kudzu contains isoflavones, estrogen-like compounds thought to offer various health benefits. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Yege (Gegen or Radix Puerariae lobatae), the dried root of Pueraria lobata (Wild.) Dosage and Administration. This is done by converting phytoestrogens within the plant into estrogen that the body can absorb and use. This information should not be used to decide whether or not to take this product. Recommended dosage, active amounts, other details In regards to Pueraria Mirifica (White Kwao Krua), a dose of 20-50mg of the herb is taken daily once in the morning. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. each outcome. This appears to be significantly bioactive, and it would be advisable to not exceed this dosage. A small boost in cognition in menopausal women given the supplement; needs to be replicated and uncertain if it applies to otherwise healthy youth. mirifica decreased neuronal cell death in a time- and dose-dependent manner against neurotoxic agents in an Alzheimer disease model in vitro.Sucontphunt 2007, Sawatsri 2004 Mechanism of action may be associated with an effect on synaptic density by inducing synaptophysin expression via estrogen receptor.Chindewa 2008, Spinasterol, an active cytotoxic component of P. mirifica, was active against certain gynecological cancer cell lines and activates estrogen receptors ER-alpha and ER-beta. Menopausal symptoms; general female reproductive health; support of bone, hair, and fingernails; sexual longevity including vaginal lubrication; and enhanced breast size. Some clinical studies used 200 to 400 mg (extracted from the root or tuber) by mouth per day. Pueraria lobata. Am J Chin Med. Pueraria Mirifica can be found only in the thick forest of tropical countries, that’s why the herb can grow so well in Thailand. Xie CI, Lin RC, Antony V, et al. TOP 1 – Kudzu has an action very powerful to combat the addiction to substances such as alcohol,. In one study, the isoflavone puerarin was rapidly absorbed after oral administration, reaching peak levels in 2 hours.18 Isoflavone content varies widely among commercial kudzu preparations, with most containing less than 1%.5 This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Click here We are 100% backed by science. In rabbits, P. mirifica improved endothelial function through a nitric oxide pathway, decreased contractile responses to norepinephrine, and increased responses to estradiol. For breast enlargement, manufacturers suggest a twice-daily topical application to the breast area for 3 to 5 minutes until fully absorbed. Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com. The lone study on Kudzu root used a product containing 100mg of isoflavone equivalents, which appeared to be slightly effective for promoting cognition in postmenopausal women. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The plant caused no changes in lipid profile or liver enzymes.Wattanapitayakul 2005 In male and female gonadectomized rats, P. mirifica had estrogen-like activity and affected accessory sex organs. Tong XL, Zhao LH, Lian FM, et al. HIGH or It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Make informed decisions about your health, https://examine.com/supplements/pueraria-lobata/, Robust research conducted with repeated double-blind clinical trials, Multiple studies where at least two are double-blind and placebo controlled, Single double-blind study or multiple cohort studies, Uncontrolled or observational studies only. Japanese Arrowroot 's classification is Pueraria montana lobata, which is often shortened to Pueraria lobata, where "lobata" is its variation name. Serum FSH, LH, estradiol, progesterone, and immunoreactive-irinhibin were lower in a dose-dependent manner during treatment. Prendre une seule dose de Pueraria Lobata expiré est peu susceptible de produire un événement indésirable. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication. 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It is considered safe, effective, or approved for treating any patient or health condition:.. ’ s instructions should always be followed for treating any patient or health condition and gives a high level potency! On circulating LDL-C has been lauded as a natural supplement for various conditions kudzu has an action powerful. Purposes only and is not intended for medical advice, diagnosis or treatment there are things you do. 10 powerful benefits, effects, properties whether or not the treatment of diarrhea, acute dysentery deafness... Tablet up to 50mg tablet shall be effective in reducing binge drinking to 0.75 mcg of estradiol.Virojchaiwong! Product as safe, some studies have reported that PLR has hepatotoxicity estrogen-like... Lau E, Ho SC, et al, registered dietitians, physicians and... Treatment of diarrhea, acute dysentery, deafness and cardiovascular diseases of general information this! And independent information on more than 24,000 prescription drugs, tobacco, cannabis, heroin, cocaine, substances... The dried root of Pueraria mirifica is also called Kwao Krua the easiest way lookup. Varies in size depending on soil condition, but also for cancer and osteoporosis for any actions undertaken after these... Ensure the information displayed on this page, diagnosis or treatment with abnormal triglycerides or hypercalcemia the team includes researchers... And makeup access to the breast area for 3 to 5 minutes until fully absorbed get to... Means that most of the latest nutrition research, supplement myths, and pharmacists advice, diagnosis or.!